Adco – Napacod Tablets

ADCO - NAPACOD is an analgesic and antipyretic used for the relief of mild to moderate pain and fever.

Do not take ADCO - NAPACOD:

• if you are hypersensitive (allergic) to ADCO - NAPACOD or any of the other ingredients of ADCO - NAPACOD.
• Contraindicated in respiratory depression, especially in the presence of cyanosis (a bluish discoloration of the skin due to poor circulation) and excessive bronchial secretion, after operations on the biliary tract, acute alcoholism, head injuries and conditions in which intracranial pressure (pressure exerted by fluids in the skull) is raised.
• It should not be given during an attack of bronchial asthma or in heart failure secondary to chronic lung disease.
• Patients taking monoamine oxidase inhibitors (antidepressants) or within 14 days of stopping such treatment.

Always take ADCO - NAPACOD exactly as described in this leaflet or as your doctor or pharmacist or nurse has told you. Check with your doctor or pharmacist or nurse if you are not sure.

Adults: 1 to 2 tablets, repeated 6 hourly if necessary

Children 7 to 12 years: ½ to 1 tablet, repeated 6 hourly if necessary

Children under 6 years: Not recommended

• Do not exceed the recommended dose.
• Do not use continuously for longer than 10 days without consulting your doctor.

If you take more ADCO - NAPACOD than you should

In the event of overdosage, consult your doctor or pharmacist. If neither is available, contact the nearest hospital or poison centre. Signs and symptoms of overdosage include:

• Nausea and vomiting;
• Narcosis;
• Feeling of exhilaration;
• Convulsions;
• Contracted pupils;
• Respiratory depression.

ADCO - NAPACOD can have side effects. Not all side effects reported for ADCO - NAPACOD are included in this leaflet. Should your general health worsen or if you experience any untoward effects while taking ADCO - NAPACOD, please consult your health care provider for advice.

If any of the following happens, stop taking / using ADCO - NAPACOD and tell your doctor immediately or go to the casualty department at your nearest hospital:

• Swelling of the hands, feet, ankles, face, lips and mouth or throat, which may cause difficulty in swallowing or breathing;
• Rash or itching;
• Fainting.

These are all very serious side effects. If you have them, you may have had a serious reaction to ADCO - NAPACOD. You may need urgent medical attention or hospitalisation.

Tell your doctor immediately or go to the casualty department at your nearest hospital if you notice any of the following:

• Chest pain;
• Angina;
• Changes in the way your heart beats, for example, if you notice it beating faster;
• Difficulty breathing;
• Signs of recurrent infections such as fever or sore throat;
• Less urine than is normal for you;
• Yellowing of the skin and eyes, dark urine, and tiredness which may be symptoms of liver problems.

These are all serious side effects. You may need urgent medical attention.

Tell your doctor if you notice any of the following:

Frequent side effects:

• Drowsiness;
• Confusion;
• Restlessness;
• Nausea;
• Vomiting;
• Constipation;
• Ureteric or biliary spasm (spasm of the tube that carries urine from the kidney to the bladder).

Less frequent side effects:

• Agranulocytosis (less white blood cells in the body);
• Thrombocytopenia (abnormally low blood platelets);
• Leukopenia (lower-than-normal white blood cells in the blood);
• Pancytopenia (lower-than-normal red and white blood cells in the blood);
• Neutropenia (deficiency of white blood cells);
• Anaemia;
• Renal colic;
• Renal failure;
• Sterile pyuria (excess presence of white blood cells in the urine);
• Hepatitis;
• Pancreatitis;
• skin rash;
• Dermatitis;

Frequency unknown:

• Pyroglutamic aciduria (5-oxoprolinuria) (metabolic condition associated with massive urinary excretion of 5-oxyproline);
• high-anion gap metabolic acidosis;
• Dry mouth;
• Vertigo;
• Bradycardia;
• Palpitations;
• Nephropathy;
• Micturition (urination);
• Urticaria;
• Pruritus;
• Sweating;
• Facial flushing;
• Hypothermia;
• Change of mood;
• Raised intracranial pressure;
• Dizziness;
• Headache;
• Miosis (excessive constriction of the pupil of the eye);
• Hypersensitivity reactions characterised by dyspnoea (shortness of breath) and orthostatic hypotension (low blood pressure).

If you notice any side effects not mentioned in this leaflet, please inform your doctor or pharmacist.

Reporting of side effects

If you get side effects, talk to your doctor or pharmacist or nurse. You can also report side effects to SAHPRA via the “6.04 Adverse Drug Reaction Reporting Form”, found online under SAHPRA’s publications: https://www.sahpra.org.za/Publications/Index/8. By reporting side effects, you can help provide more information on the safety of ADCO - NAPACOD.

• Store all medicines out of reach of children.
• Return all unused medicine to your pharmacist.
• Do not dispose of unused medicine in drains or sewerage systems (e.g., toilets).
• Store in airtight containers at or below 25 °C. Protect from light.
• KEEP OUT OF REACH OF CHILDREN.