Annin 25 mg/50 mg/100 mg Tablets

Losartan is used to treat high blood pressure (hypertension). Losartan works by blocking the action of a substance in the body that causes blood vessels to tighten. As a result, losartan relaxes blood vessels. This lowers blood pressure.

Do not take ANNIN:

• If you have ever had an unusual or allergic reaction to losartan or to any of the ingredients of the product.
• If you have or have ever had angioedema (a condition that causes difficulty swallowing or breathing and painful swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs) whilst taking previous angiotensin-converting enzyme (ACE) inhibitor medication or angiotensin receptor blockers (ARBs). You must never again take these medicines.
• If you have abnormal thickening of the heart muscle.
• If you have moderate to severe kidney disease.
• If you have narrowing of the renal arteries to both kidneys.
• If you have narrowing of the renal artery with a single kidney.
• If you have abnormal narrowing of the aortic valve.
• If you are currently taking diuretics (water tablets) that increase potassium in the blood such as triamterene, amiloride or spironolactone.
• If you have porphyria (an inherited disorder of blood pigment metabolism).
• In combination with thiazide diuretics (water that cause the body to lose potassium as well as water) such as hydrochlorothiazide, if you have Addison’s disease. Addison’s disease is a condition that results when your body produces insufficient amounts of certain hormones produced by your adrenal gland. This combination therapy must also not be used if you have severe kidney disease, are unable to urinate, or are allergic to any medicine that contains sulphur.
• If you are taking lithium, a medicine used to treat mental illness. ANNIN may increase the lithium level in your blood.
• If you are pregnant.
• If you are breastfeeding.
• For use in children. The safety and effectiveness of ANNIN in children have not been established.

Take this medicine only as directed by your doctor.

• This medicine may be taken with or without food.
• This medicine may be taken with other medicines which reduce high blood pressure.
• Dose:
• For high blood pressure: Adults - The usual starting and maintenance dose is 50 mg once a day for most patients. The dose may be increased to 100 mg once a day. Patients with blood vessels that are volume-depleted (e.g. those treated with high-dose water pills) – A starting dose of 25 mg once daily should be considered. Elderly patients and patients with kidney disease – No initial dosage adjustment is necessary. Patients with liver disease – A lower dose should be considered.

Always take ANNIN exactly as your doctor has instructed you. You should check with your doctor or pharmacist if you are unsure. If you have the impression that the effect of ANNIN is too strong or too weak, talk to your doctor or pharmacist.

ANNIN can have side effects. Contact your doctor immediately if any of the following side effects occur: Swelling of face, mouth, hands, or feet, trouble in swallowing or breathing (sudden). The following side effects may occur: Lack of energy/fatigue, abdominal pain, chest pain, swelling, rapid irregular action of heart, increased rate of heart beat, diarrhoea, indigestion, nausea, back pain, muscle cramps, headache, migraine, hives, dizziness, inability to sleep, cough, nasal congestion, inflammation of mouth and throat, sinus problems, upper respiratory infection. Not all side effects reported for this medicine are included in this leaflet. Should your general health worsen or if you experience any untoward effects while taking this medicine, please consult your doctor, pharmacist or other health care professional for advice.

Store at or below 25 °C. Do not store in the bathroom, near the kitchen sink, or in other damp places. Moisture may cause the medicine to break down. Keep blisters in the original carton until required for use. Store all medicines out of the reach of children. Return all unused medicine to your pharmacist. Do not dispose of unused medicine in drains or sewerage systems (e.g. toilets).