Medically reviewed by Bandela Mgoqi (B.Pharm, M.Pharm, MPS). Last updated on September 17, 2026.
CIPROGEN Tablets are indicated for treatment of the following infections that are caused by bacteria sensitive to ciprofloxacin:
Do not take CIPROGEN:
Severe cutaneous adverse reactions
Severe skin disorders including skin rash, itching, peeling, blistering or crusting (for example the potentially fatal Steven-Johnson syndrome or toxic epidermal necrolysis, Erythema multiforme, Acute generalised exanthematous pustulosis), small, pin point bleeding under the skin (petechiae)
Do not take CIPROGEN together with the following medicines:
The following medications should be taken 4 hours before or 1-2 hours after taking CIPROGEN:
If you are taking other medicines on a regular basis, including complementary or traditional medicines, the use of CIPROGEN with these medicines may cause undesirable interactions. Please consult your doctor, pharmacist or other healthcare professional, for advice.
CIPROGEN with food and/or drink
Do not chew the tablet, swallow whole with plenty of liquid and may be taken with or without meals.
Safety in pregnancy and lactation has not been established. If you are pregnant or breast feeding your baby while taking this medicine, please consult your doctor, pharmacist or other health care professional for advice.
CIPROGEN may impair the ability to drive or operate machinery.
The dose ranges from 250 - 750 mg twice daily and the duration of treatment depends upon the severity of the infection, clinical response and bacteriological findings. Severe and complicated infections may require prolonged therapy. The usual treatment period for acute infections is 5 – 10 days.
Streptococcal infections should be treated for at least 10 days because of the possibility of late complications.
Elderly:
Elderly people should receive doses as low as possible depending on the creatinine clearance and severity of the infection.
Lower respiratory tract infections:
Mild to moderate: 250 to 500 mg twice daily; severe or complicated: 750 mg twice daily. In cystic fibrosis patients, the dosage is 7,5 to 15 mg/kg body mass/day in two divided doses.
Urinary tract infections:
Acute uncomplicated cystitis and mild to moderate infections: 250 mg twice daily; severe or complicated infections: 500 mg twice daily.
Skin infections:
Mild to moderate infections: 500 mg twice daily; severe or complicated infections: 750 mg twice daily.
Infectious diarrhoea:
500 mg twice daily.
Bone infections:
Mild to moderate infections: 500 mg twice daily; severe or complicated infections: 750 mg twice daily. Treatment may be required for 6 weeks or longer.
Gonorrhoea:
A single dose of 250 mg, Dose adjustment for patients with kidney and/or liver insufficiency: In patients with reduced renal function, the half-life of ciprofloxacin is prolonged and the dosage needs to be adjusted. For patients with changing renal function or patients with renal impairment and hepatic insufficiency, monitoring of drug serum levels provides the most reliable basis for dose adjustment.
Always take CIPROGEN exactly as your doctor has instructed you. You should check with your doctor or pharmacist if you are unsure. If you have the impression that the effect of CIPROGEN is too strong or too weak, talk to your doctor or pharmacist.
Do not chew the tablet, swallow whole with plenty of liquid and may be taken with or without meals.
If you take more CIPROGEN than you should
In the event of overdosage, consult your doctor or pharmacist. If neither is available, seek help at the nearest hospital or poison control center.
If you forget to take use CIPROGEN
Do not take a double dose to make up for forgotten individual doses.
If you stop taking using CIPROGEN
Do not stop your treatment because you are feeling better, without consulting with your doctor.
Not all side effects reported for this medicine are included in this leaflet. Should your general health worsen while taking this medicine, please consult your doctor, pharmacist or other health care professional for advice.
CIPROGEN can have the following side effects:
Serious hypersensitivity reaction called DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) - Frequency: Not known
Reporting of side effects
If you get side effects, talk to your doctor, pharmacist or nurse. You can also report side effects to SAHPRA via the “6.04 Adverse Drug Reaction Reporting Form”, found online under SAHPRA’s publications: https://www.sahpra.org.za/Publications/Index/8. By reporting side effects, you can help provide more information on the safety of CIPROGEN.
Store below 25 °C in a dry place and protect from light.
Keep all medicines out of the reach and sight of children.
Do not store in bathrooms.
Do not use after the expiry date stated on the packaging.
Return all unused medicine to your pharmacist.
Do not dispose of unused medicine in drains or sewerage systems (e.g., toilets).
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