Endoxan 50 mg Tablets

ENDOXAN is a cytostatic or anti-cancer medicine. It works by killing cancer cells, this is sometimes called ‘chemotherapy’. It is used to treat lots of different cancers. ENDOXAN is often used together with other anti-cancer medicines or radiotherapy.

Do not take ENDOXAN if:

• you are hypersensitive (allergic) to cyclophosphamide, any of its metabolites or excipients.
• have severely reduced bone-marrow function (especially if you have previously had chemotherapy or radiotherapy).
• you have a urinary tract infection, which can be recognised as pain when passing urine (cystitis).
• you currently have any infections.
• you have a condition which decreases your ability to urinate (Urinary outflow obstruction).
• you have recently been vaccinated.
• you are pregnant or breastfeeding.

Warnings and precautions

Tell your doctor if:

• you are elderly.
• you are already having, or have recently had, radiotherapy or chemotherapy.
• you have diabetes.
• you have liver or kidney problems. Your doctor will check how well your liver and kidneys are working by doing a blood test.
• you have had your adrenal glands removed.
• you have heart problem or have had radiotherapy in the area of your heart.
• you have poor general health or are frail.

Take special care with ENDOXAN

Do not share medicines prescribed for you with any other person. Always take ENDOXAN exactly as your doctor has instructed you. You should check with your doctor or pharmacist if you are unsure. ENDOXAN should only be prescribed by doctors experienced with this medicine. The dosage of ENDOXAN will be calculated specifically for you by your doctor and depends on:

• the type of illness you have.
• how big you are (combination of your height and weight).
• your general health.
• whether you are being given other anti-cancer medicines or having radiotherapy.

ENDOXAN tablets should be taken in the morning. During or immediately after taking your dose, adequate amounts of fluid should be ingested. It is important to ensure that you empty your bladder at regular intervals. The usual dose for continuous therapy is 1 - 4 tablets (50 – 200 mg) daily. The dose may be increased or decreased by your doctor if necessary, depending on your blood test results, how you respond to the treatment, and whether you are receiving combination treatment with other medicines.

ENDOXAN can have side effects. Not all side effects reported for ENDOXAN are included in this leaflet. Should your general health worsen or if you experience any untoward effects while taking ENDOXAN, please consult your health care provider for advice.

If any of the following happens, stop taking ENDOXAN and tell your doctor immediately or go to the casualty department of your nearest hospital:

• Swelling of the hands, feet, ankles, face, lips, mouth or throat, which may cause difficulty in swallowing or breathing,
• rash or itching,
• fainting,
• yellowing of the skin and eyes, also called jaundice.

These are all very serious side effects. If you have them, you may have had a serious allergic reaction to ENDOXAN. You may need urgent medical attention or hospitalisation.

ENDOXAN must be stored at or below 25 °C. Protect from moisture. Do not use ENDOXAN after the expiry date given on the package. Store all medicines out of reach of children.