Nildin 2 g/3 g/4 g Injection

NILDIN injection contains two active ingredients, piperacillin, which is a penicillin-type antibiotic, and tazobactam, which is a medicine that prevents bacteria from inactivating piperacillin. NILDIN is used to treat bacterial infections such as those affecting your chest, abdomen, skin and gynaecological infections. NILDIN may also be used with medicines known as “aminoglycosides” to treat infections in patients who are unable to fight infections normally. NILDIN is used to treat bacterial infections in children under 12 years of age with low white blood cell counts (neutropenia) and hence decreased ability to fight infection (used in combination with an aminoglycoside antibiotic for this purpose). In hospitalised children aged 2 to 12 years, NILDIN is used to treat serious infections in the abdomen. NILDIN is not recommended to treat abdominal infections in children under 2 years.

You should not receive AURO-PIPTAZ:

• If you have ever had an unusual or allergic reaction to AURO-PIPTAZ, antibiotics known as penicillins or cephalosporins, or to medicines called beta-lactamase inhibitors.
• If you are pregnant or breastfeeding.

• Tell your doctor if you are allergic to penicillins, cephalosporins, any other medications, or have a history of allergy. Stop taking NILDIN and get emergency help if you have any of these signs of a severe allergic reaction: difficulty breathing; swelling of your face, lips, tongue or throat.
• Tell your doctor if you develop diarrhoea either during or after taking AURO-PIPTAZ. If it becomes severe or persistent, or contains blood or mucus, you should tell your doctor immediately. This may be a sign of a serious side-effect that affects the bowel. You may need urgent medical care.
• During long-term treatment, your doctor may want to take routine blood tests to monitor your kidney function, liver function and levels of blood cells.
• Tell your doctor immediately if you notice that you are bleeding or bruising more easily than normal.
• Tell your doctor if you develop symptoms of a new infection.
• If you receive doses that are higher than those recommended, you may experience seizures (convulsions).
• Tell your doctor if you are on a low sodium (salt) diet – NILDIN contains sodium.
• Tell your doctor if you have low levels of potassium in your blood or if you are taking diuretics (for heart problems or high blood pressure) or medicines for cancer. Your doctor might take a blood sample from time to time to test the levels of potassium in your blood.
• Tell your doctor if you have kidney problems, or if you receive haemodialysis treatment. Your doctor may check how well your kidneys are working before he gives you this medicine and adjust the dose to suit you.
• NILDIN may interfere with certain laboratory tests. Be sure your doctor and laboratory personnel know you are using AURO-PIPTAZ.
• NILDIN can cause interference in some tests for glucose in urine. Penicillins which are excreted in urine can cause a false-positive result. The doctor will request a test which is not affected by penicillins.

• The safety of NILDIN during pregnancy and breast-feeding has not been established.

A doctor or nurse in hospital will give NILDIN to you. It will usually be given to you as a slow injection into a vein over 30 minutes. The usual adult and juvenile dose of NILDIN is 4/0.5 g given every 8 hours. Children with infections in or around the abdomen: The length of time you will be given NILDIN depends on the type and severity of your infection. It should be given for at least five days, and for 48 hours after all signs of illness and fever have gone. If you have kidney problems, your doctor may need to adjust the dose of NILDIN or how often it is given. If you receive more NILDIN than you should: Since a healthcare professional will administer AURO-PIPTAZ, he/she will control the dosage. However, in the event of overdosage your doctor will manage the overdosage. Overdose symptoms may include nausea, vomiting, diarrhoea or seizures (convulsions). If you missed a dose of AURO-PIPTAZ: Your medication will usually be given to you by a healthcare professional. If you think you may have missed a dose, please tell your doctor or nurse.

NILDIN can have side-effects. Get emergency medical help if you have any of these signs of an allergic reaction:

• Hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

• Diarrhoea that is watery or bloody
• Easy bruising or bleeding, nose bleeds
• Widespread redness of the skin, or severe peeling of the skin
• Seizures (convulsions)
• Fever, chills, sore throat, or other signs of infection.
• Anaemia (tiredness, being short of breath and looking pale)
• Inflammation of the wall of a vein with a blood clot forming in the affected segment of vein (pain in the part of the body affected, skin redness, swelling in the part of the body affected, warmth and tenderness over the vein)

• Thrush, headache; difficulty sleeping; muscle pain and weakness; hallucinations; dry mouth; pain, swelling, warmth or redness around the site of injection; flushing; nausea (queasiness, feeling that one is about to vomit); diarrhoea; vomiting; constipation; indigestion; inflammation of the mouth; abdominal pain; skin rash; eczema; itching; hives; joint pain; increased sweating; fever; tiredness; swelling due to retained fluid; increased heart rate.

Dry powder: Vials containing sterile NILDIN dry powder may be stored at controlled room temperature (at or below 25 ºC). Keep the vial in the outer carton until required for use. Solutions: Vials containing the reconstituted solution should be used immediately or stored at 2 - 8 ºC for not more than 24 hours. Diluted solution prepared for intravenous use are stable for 24 hours under refrigeration (2 - 8 ºC) in I.V. bags. NILDIN is for single use only. Any unused portion of the reconstituted/diluted solution must be discarded (disposed of). NILDIN is usually stored and handled by a healthcare provider. If you are using NILDIN at home, store NILDIN as directed by your pharmacist or healthcare provider. Store all medicines out of the reach and sight of children.