TRINLOTAN CO can have side effects. Not all side effects reported for TRINLOTAN CO are included in this leaflet. Should your general health worsen or if you experience any untoward effects while taking TRINLOTAN CO, please consult your health care provider for advice.
If any of the following happens, stop taking TRINLOTAN CO and tell your doctor immediately or go to the casualty department at your nearest hospital:
- swelling of the hands, feet, ankles, face, lips and mouth or throat, which may cause difficulty in swallowing or breathing,
- rash or itching.
These are all very serious side effects. If you have them, you may have had a serious reaction to TRINLOTAN CO. You may need urgent medical attention or hospitalisation.
Tell your doctor immediately or go to the casualty department at your nearest hospital if you notice any of the following:
- chest pain,
- angina,
- changes in the way your heart beats, for example, if you notice it is beating faster,
- difficulty breathing.
These are all serious side effects. You may need urgent medical attention.
A very frequent side-effect is the possibility of a gradual, permanent change in your eye colour. It is also possible that TRINLOTAN CO may cause serious changes in the way your heart works. If you notice changes in your heart rate or heart function you should speak to a doctor.
Tell your doctor if you notice any of the following:
The following are known side effects of using TRINLOTAN CO:
Frequent side effects:
- Infection.
- Sinusitis.
- Upper respiratory tract infection.
- Low blood sugar levels (diabetes mellitus).
- Increased levels of cholesterol in your blood (hypercholesterolaemia)
- Feeling depressed.
- Headache.
- A gradual change in your eye colour by increasing the amount of brown pigment in the coloured part of the eye known as the iris (hyperpigmentation). If you have mixed-colour eyes (blue-brown, grey-brown, yellow-brown or green-brown) you are more likely to see this change than if you have eyes of one colour (blue, grey, green or brown eyes). Any changes in your eye colour may take years to develop. The colour change may be permanent and may be more noticeable if you use TRINLOTAN CO in only one eye. There appear to be no problems associated with the change in eye colour. The eye colour change does not continue after TRINLOTAN CO treatment is stopped.
- Eye irritation (a feeling of burning, grittiness, itching, stinging or the sensation of a foreign body in the eye).
- Changes to the eyelashes and fine hairs around the eye (increased length, thickness, pigmentation and number of eyelashes).
- Blurred vision, inflammation of the eyelids, cloudy lens of the eye (cataract), eye infection (conjunctivitis), hazy or double vision, redness of the eye, eye pain, irritation or disruption of the surface of the eye (keratitis), sensitivity to light, blind spot in your field of vision.
- High blood pressure.
- Rash or skin disorder.
- Swelling of painful joints.
Although not seen with TRINLOTAN CO, the following additional side effects have been seen with the medicines in TRINLOTAN CO (latanoprost and timolol) and therefore might occur when you use TRINLOTAN CO:
The following side effects have been seen with latanoprost:
- Frequent side effects
- Eye irritation (burning, grittiness, itching, stinging and foreign body sensation).
- Swelling of the eyelids.
- Red and watery eyes, and sensitivity to light (punctuate keratitis).
- Rash.
Other side effects
- Viral infection of the eye (herpetic keratitis).
- Dizziness.
- Changes to the eyelashes and fine hairs around the eye (increased length, thickness, pigmentation and number of eyelashes).
- Blurred vision.
- Swelling of the coloured part of the eye (iritis, uveitis).
- Swelling at the back of the eye (macular oedema).
- Swelling of the cornea.
- Corneal erosion (damage to the front layer of the eyeball).
- Changes to the direction of eyelash growth.
- Fluid filled cyst within the coloured part of the eye (iris cyst).
- Sensitivity to light.
- Eyelid changes resulting in a deepening of your eye socket.
- Skin reaction on eyelids.
- Scarring of the surface of the eye (pseudopemphigoid of ocular conjunctiva).
- Darkening of the skin around the eyes.
- Squeezing, pressure, heaviness or tightness of the chest (angina), awareness of heart rhythm (palpitations).
- Asthma, worsening of asthma, shortness of breath.
- Joint pain, muscle pain.
- Chest pain.
TRINLOTAN CO is absorbed into the blood. The timolol portion of this combination may cause similar side effects as seen with intravenous and/or oral beta-blocking medicines. Listed side effects include reactions seen within the class of beta-blockers when used for treating eye conditions:
- Generalised allergic reactions including swelling beneath the skin that can occur in areas such as the face and limbs and can obstruct the airway which may cause difficulty swallowing or breathing, hives or itchy rash, localised and generalised rash, itchiness, severe sudden life-threatening allergic reaction.
- Loss of appetite.
- Low blood glucose levels.
- Confusion.
- Anxiety.
- Altered mental state such as not knowing your location, the time or date.
- Nervousness.
- Memory loss.
- Difficulty sleeping (insomnia).
- Depression.
- Nightmares.
- Seeing or hearing things that are not real.
- Stroke.
- Reduced blood supply to the brain.
- Dizziness.
- Increases in signs and symptoms of myasthenia gravis (muscle disorder).
- Unusual sensations like pins and needles.
- Sleepiness
- Headache.
- Fainting.
- Blurred vision and detachment of the layer below the retina that contains blood vessels following filtration surgery which may cause visual disturbances.
- Corneal erosion (damage to the front layer of the eyeball).
- Irritation or disruption of the surface of the eye (keratitis).
- Double vision.
- Decreased corneal sensitivity.
- Signs and symptoms of eye irritation (e.g. burning, stinging, itching, tearing, redness).
- Dry eyes.
- Visual disturbances.
- Drooping of the upper eyelid (making the eye stay half closed).
- Swelling at the back of the eye (macular oedema).
- Inflammation of the eyelid.
- Ringing in the ears.
- Heart attack.
- Heart failure.
- Changes in the rhythm or speed of the heartbeat.
- Congestive heart failure (heart disease with shortness of breath and swelling of the feet and legs due to fluid build-up).
- Chest pain.
- A type of heart rhythm disorder.
- Slow heart rate.
- Oedema (fluid build-up).
- Palpitations.
- Worsening of angina (squeezing, pressure, heaviness or tightness of the chest).
- Cold hands and feet.
- Pain in the arms or legs while walking or using the arms.
- Low blood pressure.
- Poor blood circulation disease (Raynaud's phenomenon).
- Cough.
- Difficulty breathing.
- Stuffy nose.
- Breathing that sounds bubbly, wheezing or gasping.
- Abdominal pain.
- Vomiting.
- Diarrhoea.
- Dry mouth.
- Taste disturbance.
- Indigestion.
- Nausea.
- Pain in the lower abdomen, back, or side.
- Scarring of the surface of the eye (pseudopemphigoid).
- Skin rash with white silvery coloured appearance (psoriasiform rash) or worsening of psoriasis.
- Skin rash.
- Hair loss.
- Fever, joint pain, stiffness and swelling, butterfly-shaped rash on face (systemic lupus erythematosus).
- Muscle pain not caused by exercise.
- Sexual dysfunction.
- Decreased libido
- Scar tissue in the penis, which can cause pain and a bend to the penis (Peyronie’s disease).
- Muscle weakness.
- Tiredness.
In very rare cases, some patients with severe damage to the clear layer at the front of the eye (the cornea) have developed cloudy patches on the cornea due to calcium build-up during treatment (corneal calcification).
If you notice any side effects not mentioned in this leaflet, please inform your doctor or pharmacist.
Reporting of side effects
If you get side effects, talk to your doctor or pharmacist. You can also report side effects to SAHPRA via the Med Safety APP (Medsafety X SAHPRA) and eReporting platform (who-umc.org) found on SAHPRA website. By reporting side effects, you can help provide more information on the safety TRINLOTAN CO.
