Kytril ® 1 mg Tablets

KYTRIL contains a medicine called granisetron. This belongs to a group of medicines called “5-HT 3 receptor antagonists” which act as “anti-emetics”.

KYTRIL is used to prevent or treat nausea and vomiting (feeling and being sick) after having an operation or other treatments, such as chemotherapy or radiotherapy for cancer.

Do not use KYTRIL if you are allergic (hypersensitive) to:

• Granisetron or any of the other ingredients of KYTRIL.
• Other 5-HT 3 receptor antagonist medicines. These include dolasetron, ondansetron, palonosetron and tropisetron.

You must not be given KYTRIL if any of the above apply to you. If you are not sure, talk to your doctor, nurse or pharmacist before having KYTRIL.

Take special care with KYTRIL

Check with your doctor, nurse or pharmacist before having KYTRIL if:

• You are having problems with your bowel movements because of a blockage in your gut (intestines).
• KYTRIL has been prescribed for a child under 12 years of age. KYTRIL is not recommended for use by children under 12 years of age.

If the above applies to you, or if you are not sure, talk to your doctor, nurse or pharmacist before getting KYTRIL.

Pregnancy and Breastfeeding

You should not be given KYTRIL if you are pregnant, trying to get pregnant or breast feeding unless your doctor has told you to. If you are pregnant or breast feeding your baby while taking this medicine please consult your doctor, pharmacist or other health care professional for advice.

Driving and using machinery

KYTRIL is not likely to affect your ability to drive or use any tools or machines.

Important information about some of the ingredients of KYTRIL

KYTRIL injection is essentially “sodium free” as it contains less than 1 mmol sodium (23 mg) per 3 mg dose. KYTRIL tablets contain lactose, which is a type of sugar. If you have been told by your doctor that you cannot tolerate or digest some sugars (have intolerance to some sugars), talk to your doctor before taking this medicine.

Always take KYTRIL exactly as your doctor has told you. You should check with your doctor if you are not sure.

KYTRIL tablets:

The usual dose is either:

• One 1 mg tablet one hour or less before the start of the medical treatment that makes you feel or be sick and another 1 mg tablet 12 hours later.
• One 2 mg tablet within one hour or less before the start of the medical treatment that makes you feel or be sick.

Do not take more tablets than your doctor has told you to.

KYTRIL injection

will be given to you by your doctor or nurse. It will be given to you either as a slow injection into one of your veins (called an “intravenous infusion”). The injection usually takes 30 seconds and the infusion usually takes five minutes. The dose of KYTRIL varies from one patient to another. It depends on your age, weight and whether you are being given the medicine to prevent, or treat, nausea and vomiting. The doctor will work out how much to give you.

If you take more KYTRIL than you should

KYTRIL Tablets: If you take more KYTRIL than you should, talk to a doctor straight away.

KYTRIL injection: because KYTRIL will be given to you by a doctor or nurse it is unlikely that you will be given too much or that you will miss a dose. However, if you are worried, talk to your doctor or nurse. In the event of overdosage, consult your doctor or pharmacist. If neither is available, seek help at the nearest hospital or poison control centre.

If you forget to take KYTRIL

• If you forget to take a dose, and you feel sick, take it as soon as you remember.
• However, do not take a double dose (two doses at the same time) to make up for the forgotten dose.

Like all medicines, KYTRIL can cause side effects, although not everyone will get them.

Allergic reactions

If you have an allergic reaction, stop taking KYTRIL and tell your doctor straight away. The signs may include:

• Swelling of the throat, face, lips and mouth. This may make it difficult to breathe or swallow.
• Sudden swelling of the hands, feet or ankles.

Other possible side effects:

• Constipation
• Changes in how your liver is working (shown by blood tests).
• Abnormal (uncontrollable) body movements, shaking or muscular stiffness.
• Skin rashes.
• Headache.

If any of the side effects become serious or troublesome, or if you notice any side effects not listed in this leaflet, please tell your doctor, nurse or pharmacist.

Not all side-effects reported for this medicine are included in this leaflet. Should your general health worsen while taking this medicine, consult your doctor, pharmacist or other healthcare professional for advice.

Store all medicines out of reach of children.

• Store below 30 °C.
• Ampoules removed from the pack should be stored and protected from direct sunlight. Do not freeze.
• Do not use after the expiry date stated on the pack.
• Return unused or expired medicines to your pharmacist for safe disposal.